EPO licensing talks breakdown

Emerging EPO and EPO receptor regulators and signal transducers.

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), ra...

Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.

Erythropoietin (Epo) autocrine stimulation has been implicated in erythroblastic leukemia. To examine whether this stimulation could occur intracellularly, we developed Epo autocrine models of stimulation in the human pluripotent UT-7 cell line. Retroviral expression of Epo totally abolished the growth factor requirement of UT-7 cells. Autonomous proliferation was not cell density-dependent and...

Plenary Talks

Invited Talks

In 2009, Peter Cameron introduced a common generalization of various classes of combinatorial designs such as balanced incomplete block designs, resolvable designs and orthogonal arrays. Generalized covering and packing designs can be defined in analogous way. These objects bring into this framework further classes of designs, including covering and packing arrays, Howell designs, monogamous cy...

Hour Talks

Efforts to detect targets of recent positive selection (“selective sweeps”) in the genome frequently involve an initial screen of a region of the genome at a low density of markers (either SNPs or microsatellites), followed by a denser screen in the region flanking markers that show reduced or skewed variation relative to that predicted by an equilibrium neutral model or relative to “background...